A network algorithm for the X chromosomal exact test for Hardy–Weinberg equilibrium with multiple alleles

Statistical methodology for testing the Hardy–Weinberg equilibrium at X chromosomal variants has recently experienced considerable development. Up to a few years ago, was basically done by applying autosomal test procedures females only. At present, male alleles can be taken into account in asymptotic and exact both bi- multiallelic case. However, current multiple rely on classical full enumeration algorithm are computationally expensive, practice not feasible more than three alleles. In this article, we extend network with chromosome, achieving reduction computation times up five The performance of is assessed simulation study. Beyond four alleles, permutation is, general, approach. A detailed description given, examples indels microsatellites discussed.